CD38 is a transmembrane protein that is involved in several cellular processes such as intracellular signalling, calcium mobilization, and enzymatic activities. Increased expression of CD38 has been linked to several diseases, including cancer, autoimmune diseases, and neurodegenerative diseases.
How does increased expression of CD38 happen?
- Various types of cancer, leading to increased expression of the protein.
- CD38 gene mutations ( You genetically have an issue )
- Methylation Status & Histone
- Chronic inflammation
- Hormonal imbalances.
One of the major concerns with increased CD38 expression is its impact on NAD (Nicotinamide adenine dinucleotide) levels. NAD is a coenzyme that plays a crucial role in cellular metabolism, particularly in energy production and DNA repair. NAD also regulates the activity of sirtuins, a family of proteins implicated in aging and lifespan.
CD38 has been shown to play a role in NAD degradation, leading to decreased NAD levels in cells with high levels of CD38 expression. This decrease in NAD levels can result in cellular dysfunction and lead to the development of various diseases. For example, reduced NAD levels have been linked to insulin resistance and cardiovascular diseases, as well as neurodegenerative disorders such as Alzheimer's disease, cancer and Parkinson's disease.
In summary, NAD is essential because it plays a crucial role in cellular metabolism and regulation of sirtuins, and the expression of CD38 impacts its levels. Before you rush out and start purchasing NMN and NR to boost your NAD Levels, remember that if you have overactive CD38 expression, you may just add gas to the fire of CD38.
Want to learn how to stabilize the expression of CD38?
Key flavenoids found in the Alpha program can help regulate the expression of CD38 and can keep your Life Currency NAD at optimal levels!
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The Body Master